Dr. Jonathan Kotzin, MD, PhD, received his BS in Cellular and Molecular Biology from Stanford University, and his MD/PhD from the Medical Scientist Training at the Perelman School of Medicine. For his graduate thesis work he studied long non-coding RNA regulation of immune homeostasis in the laboratory of Dr. Jorge Henao-Mejia. He went on to complete his internal medicine residency at Brigham and Women’s Hospital, and subsequently returned to the Hospital of the University of Pennsylvania to complete his fellowship in rheumatology. During his clinical training, Dr. Kotzin has developed an interest in why certain autoimmune conditions develop in older age and often target a narrow group of tissues. Many human tissues accumulate mutations with age, and these mutations can form “neoantigens” that are newly recognized by the immune system as “foreign”. In the laboratory of Dr. E. John Wherry, he is applying advanced cancer neoantigen discovery pipelines to autoimmune diseases to better understand the impact of neoantigens on immune tolerance.